All submissions must meet the following requirements.

• 1. The manuscript has not been previously published and is not under consideration by another journal.
• 2. All authors meet recognized authorship criteria (e.g., ICMJE), have approved the final version of the manuscript, and agree to its submission.
• 3. The manuscript file complies with the journal’s formatting and structural requirements as outlined in the Author Guidelines.
• 4. A structured abstract and appropriate keywords (e.g., MeSH terms where applicable) are included.
• 5. All references are formatted according to the journal’s citation style (VANCOUVER Endnote style), and DOIs are provided where available.
• 6. A Conflict of Interest statement and Funding statement are included in Title page.
• 7. Ethical approval has been obtained from an accredited Institutional Review Board (IRB) or Ethics Committee, with approval number provided where applicable.
• 8. Informed consent has been obtained from participants where required.
• 9. For clinical trials, the study has been prospectively registered in a recognized public registry, and the registration number is provided.
• 10. A Data Availability Statement is included.
• 11. Any use of generative AI tools in manuscript preparation has been transparently disclosed, where applicable.
• 12. A cover letter addressing the scope, originality, and relevance of the manuscript has been submitted.